Une conférence à Atlanta (USA) les 11, 12 et 13 mai 2011

 

Alors que le colloque de l’hôpital de La Salpêtrière (Paris) du 31 mars, sur le thème: «Nitrate – Nitrite – Oxyde nitrique. Nouvelles perspectives pour la santé», vient à peine de se terminer [Cf. nos rubriques du 1er janvier, 13 mars, 4, 8 et 21 avril 2011], une importante conférence abordant le même sujet est annoncée aux Etats Unis. Intitulée: «Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy Conference», elle aura lieu les 11, 12 et 13 mai 2011 à l’«Emory Conference Center» d’Atlanta (Géorgie).

(voir référence ici)

Les organisateurs la présentent de la manière suivante:

«La dernière décennie a vu surgir des avancées très significatives en biologie vasculaire. Ces avancées font apparaître le rôle entrelacé et déterminant de l’ion nitrate, de l’ion nitrite et de l’oxyde nitrique en physiologie et en pathologie humaines. De l’effet principal, l’effet vasodilatateur, de cet ion nitrate, de cet ion nitrite et de l’oxyde nitrique résultent des applications thérapeutiques, tant à l’égard de maladies aiguës comme la pathologie cardiaque ischémique et la drépanocytose, qu’à l’égard de situations chroniques, comme les artériopathies périphériques, l’hypertension artérielle pulmonaire, l’insuffisance cardiaque congestive ou la transplantation d’organe […]. Bien qu’elle soit la quatrième d’une série de réunions programmées tous les deux ans, cette conférence:«Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy» sera fort différente des précédentes. Les progrès dans la compréhension de la manière dont s’effectue, en biologie, la transduction de signal par l’intermédiaire d’un gaz, le NO, et l’apparition d’une thérapeutique nouvelle basée sur les nitrates constituent des avancées fort prometteuses. L’occasion est offerte de rassembler les pensées innovantes dans un domaine en pleine ébullition [Promising steps forward in understanding the basic biology of gas-based signaling and the existing track record for nitrate-based therapeutics presents a unique opportunity to gather thought and innovation in this burgeoning area].»

Le programme annoncé est le suivant:

WEDNESDAY, MAY 11 2011: DAY 1

8:00 AM – 9:00 AM: Registration and Breakfast service

9:00 AM – 10.00 AM: Welcome and Opening Remarks David J. Lefer and Christopher G. Kevil

 

SESSION 1 HISTORY OF NITRIC OXIDE AND NITRITE RESEARCH
MODERATORS: JACK LANCASTER, PHD AND MARTIN FEELISCH, PHD

 9.10 AM – 10.10 AM: The Road to Stockholm: A Nobel Mission Louis J. Ignarro, PhD

10:10 AM – 10:40 AM: History of eNOS Regulation of Nitric Oxide Generation William C. Sessa, PhD

10:40 AM – 11:10 AM: History and New Uses of Inhaled Nitric Oxide for Pulmonary Hypertension Warren M. Zapol, MD

11:10 AM – 11:30 AM: Break

11:30 AM – 12:00 PM: History of Nitric Oxide in Shock States Timothy R. Billiar, MD

12:00 PM – 12:30 PM: Early Days of NO Research and the Emergence of Nitrite Martin Feelisch, PhD

12:30 PM – 12:55 PM: Panel Discussion

12:55 PM – 2:15 PM: Lunch: Meet the Speaker

 

SESSION 2 NITRITE BIOCONVERSION AND CELL SIGNALING MECHANISMS
MODERATORS: NEIL HOGG, PHD AND DANIEL B. KIM-SHAPIRO, PHD

2:15 PM – 2:45 PM: Recent Advances in Nitrite Homeostasis and Activation Mark T. Gladwin, MD

2:45 PM – 3:15 PM: Nitrite and Mitochondrial Biogenesis Sruti Shiva, PhD

3:15 PM – 3:45 PM: Role of Nitrite in Mediating Vasodilator Responses to Nitroglycerin in the Pulmonary Circulation Philip J. Kadowitz, PhD

3:45 PM – 4:00 PM: Break

4:00 PM – 4:30 PM: Heme Based Mechanisms of Nitrite Reduction Daniel B. Kim-Shapiro, PhD

4:30 PM – 5:00 PM: Anti-inflammatory and Metabolic Signaling Actions of Fatty Acid Nitroalkenes Francisco J. Schopfer, PhD

5:00 PM – 5:25 PM: Panel Discussion

5:25 PM – 5:30 PM: Closing Remarks Neil Hogg, PhD

 

POST- SCIENTIFIC SESSION EVENTS

5:30 PM – 7:00 PM: Poster Session

7:30 PM – 9:00 PM: Gala Banquet Dinner

 

THURSDAY, MAY 12: DAY 2

8:00 AM – 9:00 AM: Registration and Breakfast service

9:00 AM – 9:10 AM: Opening Remarks David J. Lefer, PhD and Christopher G. Kevil, PhD

 

SESSION 3 DIETARY NITRITE AND NITRATE- TRANSLATION TO THE CLINIC
MODERATORS: JON O. LUNDBERG, MD, PHD AND NIGEL BENJAMIN, MD

9:10 AM – 9:40 AM: Nature’s NO: Harnessing the Therapeutic Potential of the Nitrate-Nitrite-NO Pathway from Natural Products Nathan S. Bryan, PhD

9:40 AM – 10:10 AM: Effects of Dietary Nitrate on Blood Pressure Amrita Ahluwalia, PhD

10:10 AM – 10:40 AM: Dietary Nitrate and Mitochondrial Function Eddie Weitzberg, MD, PhD

10:40 AM – 11:00 AM: Break

11:00 AM – 11:30 AM: Dietary Nitrite Therapy for Urea Cycle Disorders Brendan Lee, MD, PhD

11:30 AM – 12:00 PM: Dietary Nitrate for Cardiovascular Disorders Jon O. Lundberg, MD, PhD

12:00 PM – 12:25 PM: Panel Discussion

12:25 PM – 2:00 PM: Lunch

 

SESSION 4 PHYSIOLOGY AND PATHOLOGY OF NITRITE AND NITRATE
MODERATORS: JAY L. ZWEIER, MD AND MARK T. GLADWIN, MD

2:00 PM – 2:30 PM: Role of Nitrite in Exercise-Mediated Cardioprotection John W. Calvert, PhD

2:30 PM – 3:00 PM: Nitrite and Therapeutic Arteriogenesis Christopher B. Pattillo, PhD

3:00 PM – 3:20 PM: Break

3:20 PM – 3:50 PM: Nitrite and Acute Lung Injury Rakesh P. Patel, PhD

3:50 PM – 4:20 PM: Nitrite and Nitrate in Doxorubicin Cardiotoxicity Lei Xi, MD

4:20 PM – 4:50 PM: Nitrite and Vascular Injury Brian S. Zuckerbraun, MD

4:50 PM – 5:20 PM: Role of Nitrate in Vascular Regeneration Tienush Rassaf, MD

5:20 PM – 5:45 PM: Panel Discussion

5:45 PM – 5:50 PM: Closing Remarks Jay L. Zweier, MD, PhD

 

FRIDAY, MAY 13: DAY 3

8:00 AM – 9:00 AM: Registration and Breakfast service

 

SESSION 5 HOT TOPICS
MODERATORS: ANDREW J. WEBB, PHD

9:00 AM – 9:05 AM: Introduction to Hot Topics To Be Announced

9:05 AM – 9:20 AM: Nitrite Protects Rat Lung Grafts From Cold Ischemia-Reperfusion Injury Toshihiro Okamoto, MD

9:20 AM – 9:35 AM: S-nitros(yl)ation Regulatesthe Cardioprotective Properties of Macrophage Migration Inhibitory Factor Peter Luedike, MD

9:35 AM – 9:50 AM: Novel Link Between Beta-3 Adrenoceptor Activation, Nitrite Signaling, and Cardioprotection Benjamin Predmore, PhD

9:50 AM – 10:05 AM : Hot Topic to be Announced

10:05 AM – 10:20 AM : Hot Topic to be Announced

 

SESSION 6 CLINICAL APPLICATION OF NITRITE AND NITRATE: TRANSLATION FROM BENCH TO BEDSIDE
MODERATOR: KENNETH R. MCCURRY, MD AND CHRISTOPHER G. KEVIL, PHD

10:20 AM – 10:50 AM: Human Safety Controversies Surrounding Dietary Nitrate and Nitrite Andrew L. Milkowski, PhD

10:50 AM – 11:15 AM: Break

11:15 AM – 11:45 AM: Nitrite Therapy Upon Resuscitation from Cardiac Arrest Cameron Dezfulian, MD

11:45 AM – 12:15 PM: Nitrite Therapy to Treat Arterial Aging Douglas R. Seals, PhD

12:15 PM – 12:45 PM: Nitrate Therapy for Peripheral Arterial Disease Jason D. Allen, PhD

12:45 PM – 1:10 PM: Panel Discussion

1:10 PM – 1:15 PM: Closing Remarks

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